Endocrine Abstracts

Presumption, nausea, bowel distension, abdominal pain and early satiety are very common in patients with Anorexia nervosa (AN). These problems may give rise to significant medical complications and may contribute to increased difficulties with refeeding and weight restoration. The aim of our study was to evaluate the influence of gatrointestinal treatment on weight gain in AN patients. Esophagogastroduodenoscopy with gastric mucose biopsy were performed in 19 AN patients (DSM-...

Introduction: Primary hyperparathyroidism (PHPT) is disorder of one or more parathyroid glands, characterized by inadequately increased PTH secretion, almost always followed by hypercalcemia. Calcitonin, secreted by parafollicular C-cells in thyroid gland, is hypocalcemic hormone which partly acts as physiological antagonist of PTH.Aim: To evaluate calcitonin response in calcium infusion test in patients with primary hyperparathyroidism.<p class="abs...

Hyponatremia can unmask hypopituitarism and secondary adrenal insufficiency due to potent non-osmotic stimulation of vasopressin release under stressful conditions. Patients and methods: In a retrospective study 25 patients (13f/12m, age 58.9±18.6 years) with hyponatremia (119.7±10.5 mmol/l) were identified among 260 in-patients treated for hypopituitarism in our department over a decade. Results: Hyponatremia was recorded in 9.6% of our patients. In 84% it was the k...

Introduction: Thyroid dysfunction may cause various psychiatric symptoms and disturbances. In addition, many factors affect the variable responses to hormone replacement. Many patients treated for Hashimoto thyroiditis(HT) report persistent impairments in general well-being despite long-term L-thyroxine (LT4) replacement and restoration of biochemical euthyroidism.Aim: To investigate the prevalence of depression and anxiety in patients with HT on long-te...

Introduction: There is an increasing awareness for intrinsic imperfections of endocrine replacement therapy affecting general well-being in the long-term. For thyroid hormone, many factors affect the variable responses to hormone replacement, like common genetic variations in deiodinase and thyroid hormone transport proteins, and the inability to provide adequate individual combined T4 and T3 therapy. Despite levothyroxine (L-T4)...

Introduction: Objective of this study was to examine the importance of metabolic syndrome (MetS) as a predictor of cardiovascular mortality in frail elderly people.Methods: Participants of the study were 253 community dwelling elderly aged 65–99 years. It was a prospective study with 32 months follow-up period. Patients were divided into four main groups according to the presence of MetS and prior major cardiovascular event (MACE): group A – pa...

Background/aims: Gaucher disease (GD) is autosomal recessive lysosomal storage disorder caused by the deficiency of enzyme glucocerebrosidase (GCD) with consequent massive acumulation of lipid-laden macrophages in various tissues including liver. It has been shown that chronic diseases with liver involvement might cause IGF1 deficiency. The aim of the study was to assess the IGF1 system in adult patients with type 1 Gaucher disease with and without enzyme replacement therapy (...

Introduction: Anorexia nervosa (AN) is a chronic disorder characterized of profound reduction in body weight and amenorrhoea. A product of complex interactions between psychological and clinical variables are important for the presence of the disease.Aim: The aim of the study was to investigate the variables which might predict full reproductive recovery of patients with anorexia nervosa.Material and methods: We studied closely mat...

Introduction: Both GH deficiency (GHD) and male hypogonadism are thought to be associated with an increased cardiovascular morbidity and mortality which is at least partly attributed to higher Insulin resistance. Potential reversibility of increased risk factors after gonadal replacement was assessed in this study, by comparing replaced and unreplaced hypogonadal men with GHD.Subjects and methods: Seventy-seven hypogonadal adult male patients with GHD ha...

Anorexia nervosa (AN) is a chronic disorder characterized of profound reduction in body weight and amenorrhoea. Despite emaciation and avoidance of cholesterol-rich food, hypercholesterolaemia is a common feature. The aim of the study was to investigate the changes in lipid metabolism with weight gain in 17 severe AN patients aged 23.8±1.6 years (DSM-IV criteria). They were compared with age-matched cohorts of 11 healthy controls (22.5±3.9 years) before and after wei...